Article

Oleic acid triggers CD4 <sup>+</sup> T cells to be metabolically rewired and poised to differentiate into proinflammatory T cell subsets upon activation

2024-02-21

Abstract excerpt

<h4>Summary</h4> T cells are the most common immune cells in atherosclerotic plaques and the function of T cells can be altered by fatty acids. Here, we show that pre-exposure of CD4 + T cells to oleic acid, an abundant fatty acid linked to cardiovascular events, results in a preferential differentiation into pro-inflammatory subsets upon activation by upregulating core metabolic pathways. RNA-sequencing of non-...

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Literature Corpus work: 9816e55c-2cfc-53bb-8349-909e7b87a0a8
DOI: 10.1101/2024.02.16.580665

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