Article

Interferon α and β induce differential transcriptional and functional metabolic phenotypes in human monocyte-derived macrophages and blunt glycolysis in response to antigenic stimuli

2023-12-16

Abstract excerpt

In the context of acute settings, the roles of type I interferons (IFNs), notably subtypes IFNα2a, 2b, and β, in modulating macrophage metabolism and contributing to host defense against viral and bacterial pathogens are well-established. However, the impact of chronic exposure to type I IFNs on macrophage metabolism, intimately linked to macrophage function, remains less understood. This study aimed to unravel th...

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Literature Corpus work: c0e6fae9-1075-5a32-a57a-16970e1d36ca
DOI: 10.1101/2023.12.16.571975

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