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Nuclear acetyl-CoA production by acetyl-CoA synthetase enables dynamic histone acetylation and gene expression in <i>Plasmodium falciparum</i>

2026-07-17

Abstract excerpt

A complex transcriptional cascade drives the two-day intraerythrocytic developmental cycle of the most virulent human malaria parasite, Plasmodium falciparum , in the human host. Genes are rapidly activated at specific times, then silenced as quickly. Transcriptional activity correlates with histone acetylation, which is modulated by acetyltransferases that use acetyl-CoA and deacetylases that produce acetate. Ac...

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Literature Corpus work
9207649b-1681-5e0d-a8b8-0e6557434f1c
DOI
10.64898/2026.07.16.738923
Open publication

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Nuclear acetyl-CoA production by acetyl-CoA synthetase enables dynamic histone acetylation and gene expression in <i>Plasmodium falciparum</i>DOI 10.64898/2026.07.16.738923
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