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Metabolic Control of Epigenetics and Its Role in CD8+ T Cell Differentiation and Function

26 Nov 2019

Abstract excerpt

Epigenetic programs that control posttranslational modifications of histone proteins and DNA itself tightly regulate transcriptional networks determining the identity and function of CD8+ T cells. Chromatin-modifying enzymes such as histone acetyltransferases and deacetylases, represent key molecular determinants of the epigenetic imprinting of CD8+ T cells. The functions of these enzymes highly depend on the...

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PMID: 31849941
DOI: 10.3389/fimmu.2019.02718

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