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Article

METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs.

Cardiovascular research - 5 Jun 2026

Cui Lei, Ho Cheng Kiu, Liang Panhong, Gao Wentao, Liu Jitao, Tian Xiao Yu, Wong Randolph, Zhou Bin, Lui Kathy O

Abstract excerpt

AIMS: N6-methyladenosine (m6A) RNA modification can govern cell fate by co- or post-transcriptionally regulating gene expression. VSMCs can undergo phenotypic switching, contributing to other cells within atherosclerotic plaques, including foam cell- and macrophage-like cells. However, the role of VSMC m6A in atherosclerosis development remains unclear. While PPAR-α and PPAR-γ have been extensively studied in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Source

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Identifiers

PMID: 41873711
DOI: 10.1093/cvr/cvag069
PMCID: PMC13261526

Genes

METTL14
METTL3
SETD1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs.PMID 41873711Read ↗

Methyltransferase-like 3-catalysed N6-methyladenosine methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis.Semantic proximity Read ↗

METTL14 promotes intimal hyperplasia through m6A-mediated control of vascular smooth muscle dedifferentiation genesSemantic proximity Read ↗

Silencing METTL3 Stabilizes Atherosclerotic Plaques by Regulating the Phenotypic Transformation of Vascular Smooth Muscle Cells via the miR-375-3p/PDK1 Axis.Semantic proximity Read ↗

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosisSemantic proximity Read ↗

Integrative Multi-Omics Analysis of IFNγ-induced Macrophages and Atherosclerotic Plaques Reveals Macrophage-dependent STAT1-Driven Transcription in AtherosclerosisSemantic proximity Read ↗

Mettl14 Mediates the Inflammatory Response of Macrophages in Atherosclerosis Through the NF-κB/IL-6 Signaling PathwaySemantic proximity Read ↗

Arachidonic and oleic acid exert distinct effects on the DNA methylomeSemantic proximity Read ↗

RNA Modification by m6A Methylation in Cardiovascular DiseaseSemantic proximity Read ↗

METTL3-Driven m6A Modification of Cpt1a Gene in High Fat Diet Related Liver Cancer Tumor Macrophages Facilitates Type II Macrophage DifferentiationSemantic proximity Read ↗

The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell–monocyte crosstalk and protects against atherosclerosis via the NF-κB pathwaySemantic proximity Read ↗

Methyltransferase-like 3 suppresses phenotypic switching of vascular smooth muscle cells by activating autophagosome formation.Semantic proximity Read ↗

miR487a-3p and miR6855-3p Facilitate Macrophage Pro-inflammatory Polarization and Lipid Accumulation in AtherosclerosisSemantic proximity Read ↗

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