Article

Nicotinamide N-methyltransferase couples inflammation and epigenetic remodelling to hepatic fibrosis

2026-07-30

Abstract excerpt

<h4>Background & aims</h4> Chronic inflammation is a key driver of progression from benign steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis. The molecular mechanisms coupling inflammatory cytokine signaling to altered hepatocyte remodeling remain incompletely understood. Here, we report that nicotinamide N -methyltransferase (NNMT) is induced by specific inflammatory cytoki...

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Literature Corpus work: f030d01b-8deb-5b2a-a5a7-c49620511794
DOI: 10.64898/2026.07.30.740978

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