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Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant <i>Mycobacterium tuberculosis</i>

2023-02-08

Abstract excerpt

Of the approximately 10 million cases of Mycobacterium tuberculosis ( Mtb ) infections each year, over 10% are resistant to the frontline antibiotic isoniazid (INH). INH resistance is predominantly caused by mutations that decrease the activity of the bacterial enzyme KatG, which mediates conversion of the pro-drug INH to its active form INH-NAD. We previously discovered an inhibitor of Mtb respiration, C10, th...

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Identifiers and source

Literature Corpus work
04e38b50-28fa-50ad-b75a-832d9bf73af0
DOI
10.1101/2023.02.06.527416
Open publication

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Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant <i>Mycobacterium tuberculosis</i>DOI 10.1101/2023.02.06.527416
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