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Discovery and functional characterization of katG mutations mediating Isoniazid resistance in Mycobacterium tuberculosis.

Diagnostic microbiology and infectious disease - 1 Nov 2026

Wang Qirong, Liu Yang, Chong Yingzhi, Song Tiantian, Yao Jiachen, Han Tiesheng, Feng Fumin

Abstract excerpt

OBJECTIVE: To identify isoniazid (INH)-resistance-associated mutations in the katG of Mycobacterium tuberculosis (MTB) using whole genome sequencing (WGS) and validate mutations through functional studies. METHODS: Clinical MTB isolates from tuberculosis patients at Shijiazhuang Fifth Hospital (June 1, 2020-June 30, 2022) were stratified into INH-resistant and INH-susceptible groups based on minimum inhibitory...

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PMID: 42251800
DOI: 10.1016/j.diagmicrobio.2026.117504

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