Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis.

Molecular microbiology - 1 Oct 2021

McNeil Matthew B, Keighley Laura M, Cook Josephine R, Cheung Chen-Yi, Cook Gregory M

Abstract excerpt

Mycobacterium tuberculosis remains a leading cause of death for which new drugs are needed. The identification of drug targets has been advanced by high-throughput and targeted genetic deletion strategies. Each though has limitations including the inability to distinguish between levels of vulnerability, lethality, and scalability as a molecular tool. Using mycobacterial CRISPR interference in combination with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Wall
Share to Clustered Regularly Interspaced Short Palindromic Repeats

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Editing

Share to Genes, Essential

Share to High-Throughput Screening Assays

Share to Metabolic Networks and Pathways

Share to RNA, Bacterial

Share to Tuberculosis

Source

Identifiers

PMID: 34346123
DOI: 10.1111/mmi.14790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPR interference identifies vulnerable cellular pathways with bactericidal phenotypes in Mycobacterium tuberculosis.PMID 34346123Read ↗

Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system.Semantic proximity Read ↗

Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis.Semantic proximity Read ↗

The phenotypic landscape of the mycobacterial cellSemantic proximity Read ↗

Genome scale CRISPRi reveals both shared and strain-specific vulnerabilities in genetically diverse drug-resistant strains of Mycobacterium tuberculosis.Semantic proximity Read ↗

Utilization of CRISPR interference to investigate the contribution of genes to pathogenesis in a macrophage model of Mycobacterium tuberculosis infectionSemantic proximity Read ↗

Illuminating host-mycobacterial interactions with functional genomic screening to inhibit mycobacterial pathogenesisSemantic proximity Read ↗

CRISPRi chemical genetics and comparative genomics identify genes mediating drug potency in Mycobacterium tuberculosisSemantic proximity Read ↗

Multiplexed transcriptional repression identifies a network of bactericidal interactions between mycobacterial respiratory complexesSemantic proximity Read ↗

High-density transposon mutagenesis in <i>Mycobacterium abscessus</i> identifies an essential penicillin-binding lipo-protein (PBP-lipo) involved in septal peptidoglycan synthesis and antibiotic sensitivitySemantic proximity Read ↗

KatG inactivation generates vulnerabilities in isoniazid resistant strains of <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

High-throughput functional genomics: A (myco)bacterial perspective.Semantic proximity Read ↗

Probing differences in gene essentiality between the human and animal adapted lineages of the <i>Mycobacterium tuberculosis</i> complex using TnSeqSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.