Article

KatG catalase deficiency confers bedaquiline hyper-susceptibility to isoniazid resistant <i>Mycobacterium tuberculosis</i>

2023-10-17

Abstract excerpt

<h4>ABSTRACT</h4> Multidrug-resistant tuberculosis (MDR-TB) is a growing source of global mortality and threatens global control of tuberculosis (TB) disease. The diarylquinoline bedaquiline (BDQ) recently emerged as a highly efficacious drug against MDR-TB, defined as resistance to the first-line drugs isoniazid (INH) and rifampin. INH resistance is primarily caused by loss-of-function mutations in the catalase...

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Literature Corpus work: bf8a17b0-c9d1-53f1-ba6c-a3e54050040f
DOI: 10.1101/2023.10.17.562707

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