Article
Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis.
Nature communications - 13 Nov 2024
Wang XinYue, Jowsey William J, Cheung Chen-Yi, Smart Caitlan J, Klaus Hannah R, Seeto Noon Ej, Waller Natalie Je, Chrisp Michael T, Peterson Amanda L, Ofori-Anyinam Boatema, Strong Emily, Nijagal Brunda, West Nicholas P, Yang Jason H, Fineran Peter C, Cook Gregory M, Jackson Simon A, McNeil Matthew B
Abstract excerpt
Drug-resistant strains of Mycobacterium tuberculosis are a major global health problem. Resistance to the front-line antibiotic isoniazid is often associated with mutations in the katG-encoded bifunctional catalase-peroxidase. We hypothesise that perturbed KatG activity would generate collateral vulnerabilities in isoniazid-resistant katG mutants, providing potential pathway targets to combat isoniazid...
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