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Elucidation of the essentiality of lumazine synthase (RibH) for <i>Mycobacterium tuberculosis</i> survival and discovery of potent inhibitors for enhanced antimycobacterial therapy

2023-07-19

Abstract excerpt

Tuberculosis (TB) continues to be a global health crisis, necessitating urgent interventions to address drug resistance and improve treatment efficacy. In this study, we validate the indispensable role of lumazine synthase (RibH), a vital enzyme in the riboflavin biosynthetic pathway, in the survival of Mycobacterium tuberculosis (M. tb) using a CRISPRi-based conditional gene knockdown strategy. We show that gene...

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Literature Corpus work
660b2cbb-ba0d-5844-ac8a-1fef7c3097d3
DOI
10.1101/2023.07.18.549608
Open publication

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Elucidation of the essentiality of lumazine synthase (RibH) for <i>Mycobacterium tuberculosis</i> survival and discovery of potent inhibitors for enhanced antimycobacterial therapyDOI 10.1101/2023.07.18.549608
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