Article

Dual role of Aβ42Os in adult hippocampal neurogenesis regulated by mGluR5 at different stages of Alzheimer's disease

2024-02-05

Abstract excerpt

<title>Abstract</title> <p>Background Alzheimer's disease (AD) is a neurodegenerative disease leading to irreversible loss of neurons in the cerebral cortex and hippocampus. Adult hippocampal neurogenesis (AHN) drops sharply correlated with cognitive status in AD patients. Beta-amyloid (Aβ), involved in the pathogenesis of AD, has been shown to positively or negatively affect the generation of new neurons. Metab...

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Literature Corpus work: e18b1053-9319-5ebf-aabd-e9fa2e8471c8
DOI: 10.21203/rs.3.rs-3898800/v1

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