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Article

mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-Dependent

12 Mar 2020

Abstract excerpt

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease and is characterized by a progressive cognitive decline in affected individuals. Current therapeutic strategies are limited in their efficacy and some have proven to be even less effective at later disease stages or after extended use. We previously demonstrated that chronic inhibition of mGluR5 signaling using the selective negative...

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PMID: 32296772
DOI: 10.1021/acsptsci.0c00013

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