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Article

Aβ pathology downregulates brain mGluR5 density in a mouse model of Alzheimer.

Neuropharmacology - 1 May 2018

Lee Minkyung, Lee Hae-June, Park In Suh, Park Ji-Ae, Kwon Yeon Ju, Ryu Young Hoon, Kim Chul Hoon, Kang Joo Hyun, Hyun In Young, Lee Kyo Chul, Choi Jae Yong

Abstract excerpt

The aim of the present study was to evaluate functional changes of mGluR5 expression in advanced Alzheimer's disease (AD) using positron emission tomography (PET) with an mGluR5 specific radiotracer ([18F]FPEB) in 5xFAD AD model. Subsequently, in the same animal, mGluR5 expression was quantified by immunoassay techniques. The non-displaceable binding potential values for mGluR5 was estimated by the Logan's...

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PMID: 29427650
DOI: 10.1016/j.neuropharm.2018.02.003

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