Article
mGluR5 ablation leads to age-related synaptic plasticity impairments and does not improve Huntington's disease phenotype.
Scientific reports - 28 May 2022
de Souza Jessica M, Ferreira-Vieira Talita H, Maciel Esther M A, Silva Nathalia C, Lima Izabella B Quirino, Doria Juliana G, Olmo Isabella G, Ribeiro Fabiola M
Abstract excerpt
Glutamate receptors, including mGluR5, are involved in learning and memory impairments triggered by aging and neurological diseases. However, each condition involves distinct molecular mechanisms. It is still unclear whether the mGluR5 cell signaling pathways involved in normal brain aging differ from those altered due to neurodegenerative disorders. Here, we employed wild type (WT), mGluR5-/-, BACHD, which is a...
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