Article

Mitochondrial dysfunction-induced KDM5A degradation impairs adult hippocampal neurogenesis in Alzheimer’s disease

2020-12-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Adult hippocampal neurogenesis (AHN) is a process of continuously generating functional mature neurons from neural stem cells in the dentate gyrus. In Alzheimer’s disease (AD) brains, amyloid pathology has deleterious effects on AHN, but molecular mechanisms for dysregulated AHN are unclear. Mitochondria of neural stem/progenitor cells play crucial roles in deter...

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Literature Corpus work: 16a46882-9a33-5c28-8320-e4e9b5888bb9
DOI: 10.21203/rs.3.rs-114597/v1

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