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Article

Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease.

Molecular brain - 29 May 2014

Hamilton Alison, Esseltine Jessica L, DeVries Rebecca A, Cregan Sean P, Ferguson Stephen S G

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) pathology occurs in part as the result of excessive production of β-amyloid (Aβ). Metabotropic glutamate receptor 5 (mGluR5) is now considered a receptor for Aβ and consequently contributes to pathogenic Aβ signaling in AD. RESULTS: Genetic deletion of mGluR5 rescues the spatial learning deficits observed in APPswe/PS1ΔE9 AD mice. Moreover, both Aβ oligomer formation and Aβ...

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Identifiers

PMID: 24886239
DOI: 10.1186/1756-6606-7-40
PMCID: PMC4050478

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