Article

p53 suppresses mutagenic RAD52 and POLθ pathways by orchestrating DNA replication restart homeostasis

2017-10-16

Abstract excerpt

<h4>ABSTRACT</h4> Classically, p53 tumor-suppressor acts in transcription, apoptosis, and cell-cycle arrest. Yet, replication-mediated genomic instability is integral to oncogenesis, and p53 mutations promote tumor progression and drug-resistance. By delineating human and murine separation-of-function p53 alleles, we find that p53 null and gain-of-function (GOF) mutations exhibit defects in restart of stalled or...

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Identifiers and source

Literature Corpus work: e16b131a-af21-54fd-b87e-68f74762c789
DOI: 10.1101/204057

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