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Article

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication.

The Journal of clinical investigation - 1 May 2017

Singh Shilpa, Vaughan Catherine A, Frum Rebecca A, Grossman Steven R, Deb Sumitra, Palit Deb Swati

Abstract excerpt

Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression. While some of the genes induced by GOF p53 have been implicated in more rapid cell proliferation compared with p53-null cancer cells, the mechanism for dependency of tumor growth on mutant p53 is unknown. This report reveals a therapeutically targetable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28394262
DOI: 10.1172/JCI87724
PMCID: PMC5409068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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