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Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?

20 Feb 2024

Abstract excerpt

Genomic instability, a hallmark of cancer, is a direct consequence of the inactivation of the tumor suppressor protein p53. Genetically modified mouse models and human tumor samples have revealed that p53 loss results in extensive chromosomal abnormalities, from copy number alterations to structural rearrangements. In this perspective article we explore the multifaceted relationship between p53, genomic...

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PMID: 38379088
DOI: 10.1038/s41418-024-01259-9

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