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Article

p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways.

eLife - 15 Jan 2018

Roy Sunetra, Tomaszowski Karl-Heinz, Luzwick Jessica W, Park Soyoung, Li Jun, Murphy Maureen, Schlacher Katharina

Abstract excerpt

Classically, p53 tumor suppressor acts in transcription, apoptosis, and cell cycle arrest. Yet, replication-mediated genomic instability is integral to oncogenesis, and p53 mutations promote tumor progression and drug-resistance. By delineating human and murine separation-of-function p53 alleles, we find that p53 null and gain-of-function (GOF) mutations exhibit defects in restart of stalled or damaged DNA...

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Share to DNA-Directed DNA Polymerase
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Genomic Instability

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Share to Rad52 DNA Repair and Recombination Protein

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 29334356
DOI: 10.7554/eLife.31723
PMCID: PMC5832412

Genes

RAD52
MRE11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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