Article
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability.
Genome biology - 16 Mar 2018
Galanos Panagiotis, Pappas George, Polyzos Alexander, Kotsinas Athanassios, Svolaki Ioanna, Giakoumakis Nickolaos N, Glytsou Christina, Pateras Ioannis S, Swain Umakanta, Souliotis Vassilis L, Georgakilas Alexandros G, Geacintov Nicholas, Scorrano Luca, Lukas Claudia, Lukas Jiri, Livneh Zvi, Lygerou Zoi, Chowdhury Dipanjan, Sørensen Claus Storgaard, Bartek Jiri, Gorgoulis Vassilis G
Abstract excerpt
BACKGROUND: Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property of p21WAF1/Cip1, showing that its chronic expression in a p53-deficient environment causes genomic instability by deregulation of the replication licensing machinery....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.