Article
Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity.
Proceedings of the National Academy of Sciences of the United States of America - 8 Mar 2022
Wang Yu-Hsiu, Ho Teresa L F, Hariharan Anushya, Goh Hui Chin, Wong Yao Liang, Verkaik Nicole S, Lee May Yin, Tam Wai Leong, van Gent Dik C, Venkitaraman Ashok R, Sheetz Michael P, Lane David P
Abstract excerpt
SignificanceOur work focuses on the critical longstanding question of the nontranscriptional role of p53 in tumor suppression. We demonstrate here that poly(ADP-ribose) polymerase (PARP)-dependent modification of p53 enables rapid recruitment of p53 to damage sites, where it in turn directs early repair pathway selection. Specifically, p53-mediated recruitment of 53BP1 at early time points promotes nonhomologous...
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