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Article

RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.

Nature communications - 24 Jul 2023

Longo Michael A, Roy Sunetra, Chen Yue, Tomaszowski Karl-Heinz, Arvai Andrew S, Pepper Jordan T, Boisvert Rebecca A, Kunnimalaiyaan Selvi, Keshvani Caezanne, Schild David, Bacolla Albino, Williams Gareth J, Tainer John A, Schlacher Katharina

Abstract excerpt

RAD51C is an enigmatic predisposition gene for breast, ovarian, and prostate cancer. Currently, missing structural and related functional understanding limits patient mutation interpretation to homology-directed repair (HDR) function analysis. Here we report the RAD51C-XRCC3 (CX3) X-ray co-crystal structure with bound ATP analog and define separable RAD51C replication stability roles informed by its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37488098
DOI: 10.1038/s41467-023-40096-1
PMCID: PMC10366140

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