Article

PPARγ activation by lipolysis-generated ligands is required for cAMP dependent <i>UCP1</i> induction in human thermogenic adipocytes

2024-08-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> The uncoupling protein 1 (UCP1) is induced in brown or “beige” adipocytes through catecholamine-induced cAMP signaling, which activates diverse transcription factors. UCP1 expression can also be enhanced by PPARγ agonists such as rosiglitazone (Rsg). However, it is unclear whether this upregulation results from de-novo differentiation of beige adipocytes from progenitor cells...

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Literature Corpus work: e0e6a44d-c5c1-5272-b17c-a8141c4f88e3
DOI: 10.1101/2024.08.10.607465

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