Article

CRISPR-enhanced human adipocyte “browning” as cell therapy for metabolic disease

2020-10-13

Abstract excerpt

Obesity and type 2 diabetes (T2D) are associated with poor tissue responses to insulin 1,2 , disturbances in glucose and lipid fluxes 3–5 and comorbidities including steatohepatitis 6 and cardiovascular disease 7,8 . Despite extensive efforts at prevention and treatment 9,10 , diabetes afflicts over 400 million people worldwide 11 . Whole body metabolism is regulated by adipose tissue depots 12–14 , which i...

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Literature Corpus work: 69729b10-ca19-52a0-8aa8-d4b1242b5a07
DOI: 10.1101/2020.10.13.337923

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