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Human Abdominal Subcutaneous-Derived Active Beige Adipocytes Carrying <i>FTO</i> rs1421085 Obesity-Risk Alleles Exert Lower Thermogenic Capacity

2023-02-01

Abstract excerpt

White adipocytes store lipids, have a large lipid droplet and few mitochondria. Brown and beige adipocytes, which produce heat, are characterized by high expression of uncoupling protein (UCP) 1, multilocular lipid droplets, and large amounts of mitochondria. The rs1421085 T-to-C single-nucleotide polymorphism (SNP) of the human FTO gene interrupts a conserved motif for ARID5B repressor, resulting in adipocyte ty...

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Literature Corpus work
58f710ab-052b-52ea-a3d4-7d9dabf55603
DOI
10.1101/2023.01.30.525688
Open publication

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