Article
AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype.
PloS one - 1 Jan 2016
Abdul-Rahman Omar, Kristóf Endre, Doan-Xuan Quang-Minh, Vida András, Nagy Lilla, Horváth Ambrus, Simon József, Maros Tamás, Szentkirályi István, Palotás Lehel, Debreceni Tamás, Csizmadia Péter, Szerafin Tamás, Fodor Tamás, Szántó Magdolna, Tóth Attila, Kiss Borbála, Bacsó Zsolt, Bai Péter
Abstract excerpt
Beige adipocytes are special cells situated in the white adipose tissue. Beige adipocytes, lacking thermogenic cues, morphologically look quite similar to regular white adipocytes, but with a markedly different response to adrenalin. White adipocytes respond to adrenergic stimuli by enhancing lipolysis, while in beige adipocytes adrenalin induces mitochondrial biogenesis too. A key step in the differentiation and...
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