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Article

Naringenin and β-carotene convert human white adipocytes to a beige phenotype and elevate hormone- stimulated lipolysis.

Frontiers in endocrinology - 1 Jan 2023

Coulter Ann A, Greenway Frank L, Zhang Dachuan, Ghosh Sujoy, Coulter Cathryn R, James Sarah L, He Yanlin, Cusimano Luke A, Rebello Candida J

Abstract excerpt

Introduction: Naringenin, a peroxisome proliferator-activated receptor (PPAR) activator found in citrus fruits, upregulates markers of thermogenesis and insulin sensitivity in human adipose tissue. Our pharmacokinetics clinical trial demonstrated that naringenin is safe and bioavailable, and our case report showed that naringenin causes weight loss and improves insulin sensitivity. PPARs form heterodimers with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37143734
DOI: 10.3389/fendo.2023.1148954
PMCID: PMC10153092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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