Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA

Abstract excerpt

Objective Functional investigation of novel gene/protein targets associated with adipocyte differentiation or function heavily relies on efficient and accessible tools to manipulate gene expression in adipocytes in vitro . Recent advances in gene-editing technologies such as CRISPR-Cas9 have not only eased gene editing but also greatly facilitated modulation of gene expression without altering the genome. Here,...

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• Share to Adipokines, Inflammation, and Metabolic Diseases
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