Article

Nuclear receptor ligand screening in an iPSC-derived <i>in vitro</i> blood-brain barrier model identifies new contributors to leptin transport

2022-05-03

Abstract excerpt

<h4>Background</h4> The peptide hormone leptin exerts its function in the brain to reduce food intake and increase energy expenditure to prevent obesity. However, most obese subjects reflect the resistance to leptin even with elevated serum leptin. Considering that leptin must cross the blood-brain barrier (BBB) in several regions to enter the brain parenchyma, altered leptin transport through the BBB might play...

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Literature Corpus work: e0da36c0-d7ff-59af-8f12-40d6044f8df5
DOI: 10.1101/2022.05.03.490335

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