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Tanycyte-Independent Control of Hypothalamic Leptin Signaling

19 Mar 2019

Abstract excerpt

Leptin is secreted by adipocytes to regulate appetite and body weight. Recent studies have reported that tanycytes actively transport circulating leptin across the brain barrier into the hypothalamus, and are required for normal levels of hypothalamic leptin signaling. However, direct evidence for leptin receptor (LepR) expression is lacking, and the effect of tanycyte-specific deletion of LepR has not been...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 30941008
DOI: 10.3389/fnins.2019.00240

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