Article

Leptin antagonism improves Rett syndrome phenotype in symptomatic <i>Mecp2-</i> deficient mice

2023-02-03

Abstract excerpt

<h4>ABSTRACT</h4> Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder caused by mutations in MECP2 . Elevated circulating levels of the adipocyte hormone leptin are consistently observed in patients and in mouse models, yet their contribution to disease progression has remained unclear. Here, we show that reducing leptin signaling—either pharmacologically or genetically— significantly alleviates...

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Literature Corpus work: f7518185-2182-56a7-b8a8-1f77da1348e9
DOI: 10.1101/2023.02.03.526251

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