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Brain Pericytes and Wnt/β-Catenin Signaling Induce Functional Blood-Brain Barrier Phenotype in Human iPSC-Derived Model.

Small methods - 1 May 2026

Nogueira Pinto Henrique, Kok Nine R, Hauger Philipp C, Karsten-van Diepen Manon, de Kok Michael, Paauw Nanne J, van der Pol Susanne M A, Nugteren-Boogaard Joline P, Hordijk Peter L, Beekhuis-Hoekstra Stephanie D, Gibbs Susan, de Wit Nienke M, de Vries Helga E

Abstract excerpt

The blood-brain barrier (BBB), formed by brain microvascular endothelial cells (BMECs), restricts vascular permeability through tight junctions, selective transporters, and low transcytosis. BBB dysfunction contributes to cerebrovascular and neurodegenerative disease, yet current human in vitro models recapitulate only a subset of BMEC features. Here, we describe a strategy generate BMECs (hiBMECs) from human...

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Identifiers

PMID: 41601407
DOI: 10.1002/smtd.202502114

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ETS1
SMAD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Brain Pericytes and Wnt/β-Catenin Signaling Induce Functional Blood-Brain Barrier Phenotype in Human iPSC-Derived Model.PMID 41601407Read ↗

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