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Article

20 years of leptin: human disorders of leptin action.

The Journal of endocrinology - 1 Oct 2014

Farooqi I Sadaf, O'Rahilly Stephen

Abstract excerpt

The discovery of leptin has provided a robust framework upon which our current understanding of the mechanisms involved in energy homeostasis has been built. In this review, we describe how the identification of humans with mutations in the genes encoding leptin and the leptin receptor and the characterisation of the associated clinical phenotypes have provided insights into the role of leptin-responsive pathways...

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Identifiers

PMID: 25232148
DOI: 10.1530/JOE-14-0480

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