Article
Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity.
Nature medicine - 1 Mar 2019
Dallner Olof S, Marinis Jill M, Lu Yi-Hsueh, Birsoy Kivanc, Werner Emory, Fayzikhodjaeva Gulya, Dill Brian D, Molina Henrik, Moscati Arden, Kutalik Zoltán, Marques-Vidal Pedro, Kilpeläinen Tuomas O, Grarup Niels, Linneberg Allan, Zhang Yinxin, Vaughan Roger, Loos Ruth J F, Lazar Mitchell A, Friedman Jeffrey M
Abstract excerpt
Quantitative changes in leptin concentration lead to alterations in food intake and body weight, but the regulatory mechanisms that control leptin gene expression are poorly understood. Here we report that fat-specific and quantitative leptin expression is controlled by redundant cis elements and trans factors interacting with the proximal promoter together with a long noncoding RNA (lncOb). Diet-induced obese...
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