Article

Brain shuttle target expression levels vary by individual, not by brain region, disease, age, or sex

2026-05-23

Abstract excerpt

Therapeutics fused to brain shuttles that exploit endogenous receptor-mediated transport at the blood–brain barrier (BBB) offer a promising strategy to deliver large molecule drugs and biologics to the CNS. A fundamental but untested assumption underlying their clinical development is that their endothelial receptor targets are consistently expressed between individuals and between patient populations. Here, we an...

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Literature Corpus work: d51bca00-42f9-5d08-8c72-74ecb670b8cb
DOI: 10.64898/2026.05.21.726908

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