Article

Forward Programming Identifies Inducers of Blood-Brain Barrier Properties in Human Pluripotent Stem Cell-Derived Endothelial Cells

2026-02-03

Abstract excerpt

Brain microvascular endothelial cells (BMECs) forming the blood-brain barrier (BBB) maintain brain homeostasis through specialized properties such as tight junctions, efflux transporters, and low levels of transcytosis. However, mechanisms governing induction of BBB properties during development remain poorly understood. We mined single-cell RNA sequencing datasets to identify transcription factors (TFs) critical...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b10e7371-3fdb-55f2-99bf-e09bf2a11675
DOI: 10.64898/2026.02.02.699492

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Forward Programming Identifies Inducers of Blood-Brain Barrier Properties in Human Pluripotent Stem Cell-Derived Endothelial CellsDOI 10.64898/2026.02.02.699492Read

Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cellsSemantic proximity Read

Pericytes and Wnt signaling induce functional blood-brain barrier phenotype in human iPSC-based modelSemantic proximity Read

Brain Pericytes and Wnt/β-Catenin Signaling Induce Functional Blood-Brain Barrier Phenotype in Human iPSC-Derived Model.Semantic proximity Read

Human induced pluripotent stem cell-derived neuroectodermal epithelial cells mistaken for blood-brain barrier-forming endothelial cellsSemantic proximity Read

Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells.Semantic proximity Read

Combinatorial Modulation of Wnt, STAT3, TGF-β, and Tie2 Pathways Drives Brain Endothelial Cell-Like Differentiation from hiPSCsSemantic proximity Read

Generation of hiPSC-derived brain microvascular endothelial cells using a combination of directed differentiation and transcriptional reprogramming strategiesSemantic proximity Read

Synergistic induction of blood-brain barrier propertiesSemantic proximity Read

Inducers of the endothelial cell barrier identified through chemogenomic screening in genome-edited hPSC-endothelial cellsSemantic proximity Read

Integrative multi-omic profiling of adult mouse brain endothelial cells and potential implications in Alzheimer’s diseaseSemantic proximity Read

3D organoids containing endothelial and neural cells generation by serial inductions of differentiation on human iPSC-derived embryoid bodiesSemantic proximity Read

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells.Semantic proximity Read