Translational control of cell plasticity drives 5-FU tolerance

Abstract excerpt

All routine clinical treatments for colorectal cancer include 5-fluorouracil (5-FU), which cannot counteract recurrence and metastases formation. As the pyrimidine analog 5-FU can impact multiple pathways including both DNA and RNA metabolism, studying its mode of actions could lead to improved therapies. Using a dedicated reporter system for lineage-tracing and deep translatome profiling we demonstrate that 5-FU...

Topics

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• Cancer Cells and Metastasis
• Colorectal Neoplasms
• MAP Kinase Signaling System
• Mitogen-Activated Protein Kinases
• Mutation
• Oncogenes
• Pluripotent Stem Cells Research
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

e0da07b4-f26a-5f61-81d6-e2f82f54c8bc

DOI

10.1101/2024.07.03.601826