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Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer

1 Feb 2025

Abstract excerpt

Targeting cancer stem cells (CSCs) is crucial for effective cancer treatment, yet resistance mechanisms to LGR5+ CSC depletion in WNT-driven colorectal cancer (CRC) remain elusive. In the present study, we revealed that mutant intestinal stem cells (SCs) depart from their canonical identity, traversing a dynamic phenotypic spectrum. This enhanced plasticity is initiated by oncofetal (OnF) reprogramming, driven by...

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PMID: 39930084
DOI: 10.1038/s41588-024-02058-1

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