Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.

doi:10.15252/emmm.202114123

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Article

Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.

EMBO molecular medicine - 7 Oct 2021

Uhlitz Florian, Bischoff Philip, Peidli Stefan, Sieber Anja, Trinks Alexandra, Lüthen Mareen, Obermayer Benedikt, Blanc Eric, Ruchiy Yana, Sell Thomas, Mamlouk Soulafa, Arsie Roberto, Wei Tzu-Ting, Klotz-Noack Kathleen, Schwarz Roland F, Sawitzki Birgit, Kamphues Carsten, Beule Dieter, Landthaler Markus, Sers Christine, Horst David, Blüthgen Nils, Morkel Markus

Abstract excerpt

In colorectal cancer, oncogenic mutations transform a hierarchically organized and homeostatic epithelium into invasive cancer tissue lacking visible organization. We sought to define transcriptional states of colorectal cancer cells and signals controlling their development by performing single-cell transcriptome analysis of tumors and matched non-cancerous tissues of twelve colorectal cancer patients. We...

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PMID: 34409732
DOI: 10.15252/emmm.202114123
PMCID: PMC8495451

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