Article
Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer
2020-01-11
Abstract excerpt
In colorectal cancer, oncogenic mutations transform a hierarchically organized and homeostatic epithelium into invasive cancer tissue lacking visible organization. We sought to define colorectal cancer cell types and signals controlling their development. More than 30,000 epithelial single cell transcriptomes of tumors and matched non-cancerous tissues of twelve colorectal cancer patients were clustered into six p...
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Identifiers and source
- Literature Corpus work
- 3d09e7b3-1fd9-52db-bf59-4aa555348e39
- DOI
- 10.1101/2020.01.10.901579