Article

Multi-compartment immune and tumor cell reprogramming by IFNα2 overcomes colon cancer immunotherapy resistance

2026-07-01

Abstract excerpt

<h4>SUMMARY</h4> Tumor cell PD-L1 represses IFN signaling to limit anti-tumor immunity, despite an IFN-responsive immunophenotype predicting colorectal cancer response to immune checkpoint inhibitor therapy. Lipid nanoparticle (LNP)-encapsulated IFNα2-encoding nanoplasmid (LNP-mIFNα2) gene therapy suppresses tumor progression, however, the underlying mechanism and therapeutic trade-offs of the accompanying proinf...

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Literature Corpus work: dc9b9852-8a1a-526f-b991-1f46efc18e75
DOI: 10.64898/2026.06.26.734809

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