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Spatial multi-omics and single-cell transcriptomics uncover senescence-associated cellular programs during colon adenoma to cancer progression

2026-08-07

Abstract excerpt

Colorectal cancer develops through a normal-adenoma-carcinoma sequence, yet only 5-10% of adenomas progress to malignancy, and the cellular programs governing that sequence remain poorly defined. Here we generate a spatial multi-omics atlas of human colon adenomas, combining Visium CytAssist and protein co-detection across 24 nonadvanced and advanced tubular adenomas with single-cell resolution Xenium Prime 5K pro...

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Literature Corpus work
868b6b6d-ab1e-5fb7-b8b3-5d40c8d19ae8
DOI
10.64898/2026.08.06.743310
Open publication

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Spatial multi-omics and single-cell transcriptomics uncover senescence-associated cellular programs during colon adenoma to cancer progressionDOI 10.64898/2026.08.06.743310
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