Article

Alteration of ribosome function upon 5-fluorouracil treatment favours cancer cell drug-tolerance

2020-06-05

Abstract excerpt

Partial response to chemotherapy leads to disease resurgence. Upon treatment, a subpopulation of cancer cells, called drug-tolerant persistent cells, display a transitory drug tolerance that lead to treatment resistance 1,2 . Though drug-tolerance mechanisms remain poorly known, they have been linked to non-genomic processes, including epigenetics, stemness and dormancy 2–4 . 5-fluorouracil (5-FU), the most wide...

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Literature Corpus work: e3bd090e-7014-5ea8-abb3-6fec99d918e7
DOI: 10.1101/2020.06.04.131201

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