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Lineage Plasticity in Cancer Progression and Treatment

1 Dec 2017

Abstract excerpt

Historically, it has been widely presumed that differentiated cells are determined during development and become irreversibly committed to their designated fates. In certain circumstances, however, differentiated cells can display plasticity by changing their identity, either by dedifferentiation to a progenitor-like state or by transdifferentiation to an alternative differentiated cell type. Such cellular...

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PMID: 29756093
DOI: 10.1146/annurev-cancerbio-030617-050224

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