Article

TGF-β1-induced differentiation enhances chemotherapy response in metastatic colorectal cancer organoids

2026-06-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> In metastatic colorectal cancer, systemic therapies frequently fail, partly due to underlying phenotypic plasticity rooted in pre-existing multi-type cell populations. Intratumoral lineage hierarchies within colorectal tumors require renovated efforts to decode growth principles, design rational therapeutic approaches, and accurately interpret drug response. Understanding th...

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Literature Corpus work: a231fb0c-04cf-5af8-85bd-2d8e7c39c25e
DOI: 10.64898/2026.06.04.730067

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