Article

RNA-Sequencing of Long-Term Label-Retaining Colon Cancer Stem Cells Identifies Novel Regulators of Quiescence

2021-02-02

Abstract excerpt

<h4>SUMMARY</h4> Recent data suggests that colon tumors contain a subpopulation of therapy resistant quiescent cancer stem cells (qCSCs) that are the source of relapse following treatment. Here, using colon cancer patient-derived organoids (PDOs) and xenograft (PDX) models, we identify a rare population of long-term label-retaining (PKH26 Positive ) qCSCs that can re-enter the cell cycle to generate new tumors....

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Literature Corpus work: 5aea3837-9bb4-54b2-86ae-2c17490347c7
DOI: 10.1101/2021.02.02.429354

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