Article

EIF6 conditions drug-tolerant persister-like transdifferentiation in small cell lung carcinoma

2024-05-30

Abstract excerpt

<title>Abstract</title> <p>Drug-tolerant persister cells withstand treatments by adapting their identity through lineage-dependent plasticity during systemic anti-cancer therapies. This phenomenon is evident in small-cell lung carcinoma (SCLC), a lethal neuroendocrine cancer initially responsive (60-80%) to platinum-based chemotherapy but succumbing to resistance within 6 months in advanced stages. This resistanc...

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Literature Corpus work: 1b9bb2e2-3d27-5f3f-9304-fd8b44f50dc6
DOI: 10.21203/rs.3.rs-4232167/v1

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